ultra high pressure homogenizer for pilot-scale testing

Ultra-High Pressure Homogenizer Overview

The design of the ultra-high pressure homogenizer takes into account the flexibility of laboratory equipment and the stability of industrial equipment, and is an important bridge between laboratory and industrialized production.

Features

• High-pressure system design: three to four high-strength ceramic plungers are used to drive the system alternately, providing stable pulse output and significantly reducing material pressure fluctuations. The system comes standard with a lubrication and cooling system, which significantly extends the life of the plunger and sealing components.
• Intelligent control platform: equipped with high sensitivity touch screen control system, the main control components using the German Siemens brand, the interface is intuitive, support for recipe storage, automatic pressure adjustment, temperature monitoring, operation data traceability and other functions. It is equipped with three-level authority management, which is suitable for enterprise-level research development management needs.
• Safety and monitoring system: equipped with digital pressure and temperature sensors, real-time monitoring of key operating parameters. With over-voltage, over-temperature, no-load startup, abnormal power failure and other multiple protection alarm mechanisms to ensure the safety of equipment operation and personnel safety.
• Strong process adaptability: flexible range of processing volume, processing volume of 15 liters, suitable for pilot scale 100 liters to 500 liters of small batch continuous testing. Working pressure up to 1800bar, suitable for a variety of high shear requirements of the material.
• Clean process design: material contact parts are made of 316L stainless steel, ceramics, zirconia, diamond and other corrosion-resistant materials, in line with FDA and GMP certification requirements. It supports CIP online cleaning function to meet the demand of sterile and clean process.
• Cooling and temperature control technology: online cooling module combined with high efficiency sanitary tube heat exchanger to realize low temperature control in high pressure homogenization process, which is suitable for processing heat-sensitive active substances such as enzyme preparations, vaccines, biological products and so on.
• Energy saving and low maintenance: Adopting frequency conversion motor drive, matched with automatic energy-saving speed regulation mechanism, more stable operation, lower energy consumption and smaller maintenance cost. Modular design of components, easy to disassemble and replace.

Working Principle

1. Shear effect: when the high-pressure fluid passes through the narrower channel, the flow rate increases sharply, and strong shear occurs between the fluid layers, resulting in particle fracture and refinement.
2. Cavitation effect: in the homogeneous valve high-speed channel area, the instantaneous pressure difference caused by local cavitation, bubble bursting to form shock waves, destroying the particle structure.
3. Collision and impact: material high-speed impact homogeneous valve surface or collision with each other, the particle structure further depolymerization, to achieve micron to nanometer particle size distribution.
4. Through this series of physical processes, the solid particles in the material, liquid droplets or cell walls are quickly broken or emulsified, so as to achieve stable dispersion, particle size uniformity effect.

Applications

• Pharmaceutical industry: vaccine, liposome, nano drug, protein solution, cell lysis, injection, emulsion and so on.
• Biotechnology: enzyme preparation, microbial cell crushing, homogenization of biological fermentation liquid.
• Food and beverage: fruit juice, dairy products, plant protein drinks, condiments, sauces and other microemulsification treatment.
• Cosmetics and daily chemicals: nano emulsion, cream, serum, flavor emulsification, etc.
• Chemical and new energy: nano-paste, graphene dispersion, lithium battery materials, battery paste, coating ink, etc..